depressive disorder — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7061	Duloxetine		Serotonin Transporter
	Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.		Serotonin Transporter
T1279	Vilazodone	SB659746A,EMD 68843	5-HT Receptor , Serotonin Transporter
	Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from...		5-HT Receptor , Serotonin Transporter
T15799	LY2940094	LY-2940094	Opioid Receptor
	LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot...		Opioid Receptor
T14782	Brilaroxazine	RP5063	Dopamine Receptor , 5-HT Receptor
	Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...		Dopamine Receptor , 5-HT Receptor
T7805	GW791343 dihydrochloride	GW791343 (HCl)	P2X Receptor
	GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.		P2X Receptor
T3933	Jatrorrhizine	Yatrorizine,neprotin	MAO , 5-HT Receptor , Antibacterial , AChE
	Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...		MAO , 5-HT Receptor , Antibacterial , AChE
T1445	Agomelatine	Thymanax,S-20098,Valdoxan	Melatonin Receptor , 5-HT Receptor
	Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.		Melatonin Receptor , 5-HT Receptor
T4912	Jatrorrhizine chloride	Yatrorhizine chloride,Neprotine chloride	Others , 5-HT Receptor , OCT , Antibacterial , AChE
	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...		Others , 5-HT Receptor , OCT , Antibacterial , AChE
T1471	Duloxetine hydrochloride	Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl	Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i...
T6526	GW791343 trihydrochloride	GW791343 3HCl	P2X Receptor
	GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.		P2X Receptor
T27599	Imiloxan	RS21361,RS 21361,RS-21361
	Imiloxan, an α2 adrenergic receptor antagonist, is used potentially for the treatment of major depressive disorder.
T22453	Venlafaxine	Wy 45030	Serotonin Transporter
	Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.		Serotonin Transporter
T68172	Zalospirone		5-HT Receptor
	Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.		5-HT Receptor
T22442	Trazodone	AF-1161	5-HT Receptor
	Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.		5-HT Receptor
T32737	Liafensine	BMS820836,BMS 820836,DB104,BMS-820836	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and centra...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
T6232	Vilazodone Hydrochloride	SB659746A,EMD 68843,Vilazodone HCl	Others , 5-HT Receptor , Serotonin Transporter
	Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.		Others , 5-HT Receptor , Serotonin Transporter
T21013	Clomipramine	Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina	5-HT Receptor
	Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su...		5-HT Receptor
T64317	ZZL-7		Serotonin Transporter
	ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the ...		Serotonin Transporter
T69364	Elzasonan
	Elzasonan is a selective 5-hydroxytryptamine 1B receptor antagonist used to treat patients with major depressive disorder and obsessive compulsive disorder.
T71389	Fluoxetine oxalate
	Fluoxetine oxalate is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorde...